12th World Congress on Alternatives and Animal Use in the Life Sciences

Monday 28^th August 2023

• 09.00-10.30 Session S455: Progress in Quantifying Adverse Outcome Pathways to Support Next Generation Risk Assessment. Chairs: Mark Cronin and Huan Yang
  • #512 – The Roles of qAOPs in Exposure-Led NGRA: Benefits and Limitations. (PDF 2.46 MB) Alistair Middleton¹, Andrew White¹ (¹Unilever)
• 11.00-12.30 Session S416: Replacement at the Forefront – Implementing Animal-Free Science Education. Chairs: Janneke Hogervorst and Daniela Salvatori
  • #604 – Accelerating the Transition to Animal-Free Safety Assessment: what can we learn from the Cosmetics Animal Testing bans? (PDF 3.14 MB) Gavin Maxwell¹, Julia Fentem¹, Ian Malcomber¹, Carl Westmoreland¹ (¹Unilever)
• 14.00-16.00 Session S400: Adversity Reinvented: Non-Animal Frameworks for Predictive & Protective Decision-Making. Chairs: Patience Browne and Donna MacMillan
  • #381 – Tiered approaches for Next Generation Risk Assessment (NGRA) of chemicals: Two case studies. (PDF 1.32 MB) Maria Teresa Baltazar¹, Paul Carmichael¹, Sarah Hatherell¹, Predrag Kukic¹, Sophie Malcomber¹, Alistair Middleton¹, Iris Müller¹, Georgia Reynolds¹, Liz Tulum¹, Kathryn Wolton¹, Adam Wood¹. (¹Unilever)
• 14.00-16.00 Session S450: New Approach Methods for Developmental and Reproductive Toxicity Testing. Chairs: Lena Smirnova and Jessica Palmer
  • #517 – Practical Application of New Approach Methods in Developmental and Reproductive Toxicity (DART) Testing. (PDF 1.84 MB) Iris Müller¹, Paul Carmichael¹, Matthew Dent¹, Luke Flatt², Jade Houghton¹, Amer Jamalpoor², Predrag Kukic¹, Hequn Li¹, Alistair Middleton¹, Gopal Pawar¹, Claire Peart¹, Katarzyna Przybylak¹, Magdalena Sawicka¹, Sandrine Spriggs¹, Ramya Rajagopal¹, Katy Wilson¹, Kathryn Wolton¹. (¹Unilever; ²Toxys)

Tuesday 29^th August 2023

• 9.00-10.30 Session S411: A Decade of Progress: Lessons from Animal-Free Cosmetics Policy Worldwide. Chairs: Aviva Vetter and Erin Hill
  • #602 – Dissemination of Science: Animal-Free Safety Assessment (AFSA) Education and Training modules. (PDF 2.32 MB) Gavin Maxwell¹, Catherine Willett². (¹Unilever; ²Humane Society International (HSI))
• 11.00-12.30 Session S429: A World of 3R Centres: Unity in Diversity. Chairs: Hajime Kojima and Adrian Smith
  • #679 – The European Partnership for Alternative Approaches to Animal Testing (EPAA): Accelerating the Transition to Animal-Free, Sustainable Innovation. (PDF 2.77 MB) Gavin Maxwell^1,2, Charles Laroche^2,3, Irene Manou², Pascale Oosterbosch^2,4, Dorota Przyludzka^2,4, Zvonimir Zvonar², Giacomo Mattino’^2,4. (¹Unilever; ²EPAA; ³AISE; ⁴DG GROW, European Commission)
• 17.30-19.30 #UseScienceNotAnimals World Café
  • Welcome to the #UseScienceNotAnimals World Café where for one night only, we’re serving the world of Next-Gen Safety Science! So please come along, relax, & enjoy delicious vegan food, refreshing drinks, and the chance to meet & engage with our:
    • Debaters & Science Slammers
    • Education & training providers
    • Tools & approach experts
    • Safety Science Mentors
    • Scavenger Hunt
  • Sponsored by Unilever and organised in partnership with Humane Society International (HSI), Institute for In Vitro Science (IIVS), Physicians Committee for Responsible Medicine (PCRM) & WC12 local organising committee.

Download the World Cafe Map (PDF 499.07 KB)

Wednesday 30^th August 2023

• 11.00-12.30 Session S410: NAMs in Practice: Fit-for-Purpose NGRA across sectors: Chairs: Anne Gourmelon and Maria Baltazar
  • #361 – EPAA Project: Use of New Approach Methodologies (NAMs) in Regulatory decisions for Chemical Safety. (PDF 1.34 MB) Pilar Prieto¹, Carl Westmoreland², Catherine Mahony³, Gavin Maxwell², Irene Manou⁴, Charles Laroche⁵ (¹European Commission, Joint Research Centre; ²Unilever, SEAC; ³Procter and Gamble Technical Centre Ltd; ⁴EPAA Industry Secretariat; ⁵AISE)
  • #700 – Development and Execution of an Occupational Next Generation Risk Assessment (NGRA) on an Exclusive Use Cosmetic Ingredient under EU REACH: A Case Study on C12-15 Alkyl Benzoate. James Dawick¹, Lauren Kavanagh¹, Matthew Dent². (¹Innospec Ltd.; ²Unilever, SEAC)
• 11.00-12.30 Session S431 (Workshop): Industry, Regulators, and Human Health: Whose Onus to Defend Animal Data? Chairs: Harald Schlatter and Mike Wade.
  • Panellists: Gavin Maxwell¹ , Yadvinder Bhuller², Nicole Kleinstreuer³, Troy Seidle⁴, Jean-Lou Dorne⁵, Agnes Karmaus⁶. (¹Unilever, ²Health Canada, ³NICEATM, NIEHS/NIH, ⁴Humane Society International, ⁵European Food Safety Authority, ⁶Syngenta)
• 14.00-16.00 Session S404: Is it Good Enough? Establishing Scientific Confidence in New Approach Methods. Chairs: Anne Gourmelon and Anna van der Zalm
  • #508 – Evaluating New Approach Methodologies for use in Next Generation Risk Assessment. (PDF 2.88 MB) Alistair Middleton, Unilever

Thursday 31^st August 2023

• 09.00-10.30 Session 459: What’s New in Skin Sensitization? Chairs: Sebastian Hoffmann and Petra Kern
  • #600 – The SARA-ICE Model for Predicting Skin Sensitizer Potency (PDF 1.46 MB). Gavin Maxwell¹, Georgia Reynolds¹, Joe Reynolds¹, Nicola Gilmour¹, Judy Strickland², Emily N. Reinke², Dori Germolec³, Jim Truax², David G. Allen², Nicole Kleinstreuer⁴. (¹Unilever; ²Inotiv; ³NIH/NIEHS/DTT/STB/NICEATM; ⁴NIH, NIEHS, DTT, PTB, NICEATM)

Poster presentations:

• Poster Board Number B69, Abstract #281 – Combining in silico and in vitro tools for assessing inhalation hazard of sodium dodecyl sulphate aerosols. (PDF 1.41 MB) Sreyoshee Sengupta¹, Hugh Barlow², Maria Baltazar², Jorid B. Sørli¹. (¹The National Research Centre for the Working Environment, Denmark; ²Unilever, SEAC)
• Poster Board Number A7, Abstract #360 – An Exposure-led approach to Worker Safety Assessment of Sodium 2-Hydroxyethane Sulphonate using New Approach Methodologies. (PDF 938.21 KB) Carl Westmoreland¹, Catherine Breffa², Caroline Chaine³, Susann Fayyaz², Fabian Grimm², Steve Gutsell¹, Reiko Kiwamoto⁴, MoungSook Lee², Colin Smith⁵, Willemien Wieland⁵, Adam Wood¹, Tristan Zellamann⁶. (¹Unilever, SEAC; ²Clariant Produkte Deutschland GmbH; ³Vantage Speciality Chemicals; ⁴Unilever, Regulatory Affairs; ⁵Environmental Resources Management Limited; ⁶Vantage Leuna GmbH)

#UseScienceNotAnimals

Related Links:

• www.wc12canada.org