Society of Environmental Toxicology and Chemistry Europe 34th Annual Meeting

The 34^th SETAC Europe Annual Meeting to be held in Sevilla, Spain on the 5-9^th May 2024 will gather approximately 2500 scientists and practitioners from Academia, Industry, Government and Civil Societies exploring the overarching theme "Science-Based Solutions in Times of Crisis: Integrating Science and Policy for Environmental Challenges.". Throughout the week SEAC Environmental Safety and Sustainability scientists and our network of external collaborators will contribute a substantial number of sessions, oral presentations and posters leading to discussions on latest scientific developments living up to SETAC slogan “Environmental Quality Through Science®”.

Unilever and Partners Oral Presentations

3.01.B.T-03 - Using An In Silico NAMs Approach To Predict Bioaccumulation In Fish: A Case Study For Anionic Surfactants Within A Regulatory Context (PDF 1.06 MB)

Jayne Roberts¹, Andrea Gredelj^1,2, Steve Gutsell¹, Geoffrey Hodges¹, James Dawick³, Lauren McAnally³ and Marc Geurts⁴, (1)Unilever - Safety and Environmental Assurance Centre (SEAC), United Kingdom, (2)Norwegian Geotechnical Institute (NGI), Oslo, Norway, (3)Innospec Limited, United Kingdom, (4)Nouryon Chemicals B.V., Arnhem, Netherlands

1.11.T-03 - Integration of Endocrine Modalities into an Existing Mechanism of Action-based In Silico Scheme for use in Environmental Risk Assessment (PDF 1000.02 KB)

James W. Firman¹, Franklin Bauer², Geoffrey Hodges³, Gaspard Levet², Bruno Campos³, Jayne Roberts³, Steve Gutsell³, Homa Basiri¹, Paul Thomas² and Mark Cronin¹, (1)Liverpool John Moores University, United Kingdom, (2)KREATiS, France, (3)Unilever - Safety and Environmental Assurance Centre (SEAC), United Kingdom

1.11.T-04 - Predicting Aquatic Toxicity of Surfactants Using Simulated Coarse-Grained Membrane-Water Coefficient Derived QSARs (PDF 864.37 KB)

Andrea Gredelj^1,2, Jayne Roberts¹, Elin Barrett¹, Eoin Kearney³, Nicola Haywood¹, Mark Miller³ and Geoffrey Hodges¹, (1)Unilever - Safety and Environmental Assurance Centre (SEAC), Sharnbrook, United Kingdom, (2)Norwegian Geotechnical Institute (NGI), Oslo, Norway, (3)Department of Chemistry, Durham University, Durham, United Kingdom

Unilever and Partners Poster Presentations

7.04.P-We570 - Sustainable product innovations for fast-moving consumer goods – Learning from companies’ experiences for a more effective and accessible ‘Safe and Sustainable by Design’ framework (PDF 900.64 KB)

Florence Bohnes, Ian Malcomber, Sarah Sim, David Mason, Gordon Riley, Clare Rodseth, Evita Vandenbossche-Goddard, Unilever R&D Colworth, Sharnbrook, United Kingdom

5.05.P-Mo495 - Improving substance coverage for more accurate ecotoxicity normalisation factors – A Consortium-based approach (PDF 410.1 KB)

Florence Bohnes^1,2, Mathilde Kolenda^2,3, Jad Zoghaib^2,4, (1)Unilever R&D Colworth, Sharnbrook, United Kingdom, (2)EcoBeautyScore Consortium, (3)Quantis, Paris, France, (4)L'Oréal Recherche & Innovation, Paris, France

5.04.P-Tu497 - Improving the robustness of freshwater ecotoxicity impact assessment of cosmetic products in life cycle assessment: summary and illustration of the work conducted by the EcoBeautyScore Consortium (PDF 867.39 KB)

Alessio Aufoujal², Florence Bohnes¹, Laurent Gilbert³, Mathilde Kolenda², Monica Lam⁴, Sacha Laruelle⁵, Jacques L'Haridon, PhD⁶, Olena Onyshchenko⁷, Jennifer K. Saxe⁸, Pascal Seel⁹, Harald Streicher¹⁰ and Jad Zoghaib¹¹, (1)Unilever R&D Colworth, Sharnbrook, United Kingdom, (2)Quantis, Paris, France, (3)L’Oréal Recherche & Innovation, Aulnay-sous-Bois, France, (4)Procter & Gamble, ., United States, (5)LVMH Recherche Parfums & Cosmétiques, ., France, (6)L'Oréal Recherche & Innovation, Aulnay-sous-Bois, France, (7)Henkel AG & Co. KGaA., Düsseldorf, Germany, (8)KENVUE, Skillman, NJ, (9)Environmental Strategy & Human Rights, Beiersdorf, Germany, (10)Beiersdorf, Germany, (11)L'Oréal Recherche & Innovation, Paris, France

1.11.P-Th068 - Development of an Ontology-Driven In Silico Profiler for the Evaluation of Potential Endocrine Disruptors (PDF 1.47 MB).

Mark Cronin¹, Homa Basiri¹, Franklin Bauer², Bruno Campos³, James W. Firman¹, Steve Gutsell³, Geoffrey Hodges³, Gaspard Levet², Jayne Roberts³ and Paul Thomas², (1)Liverpool John Moores University, United Kingdom, (2)KREATiS, France, (3)Unilever - Safety and Environmental Assurance Centre (SEAC), United Kingdom

3.01.P-Th136 - Assessment of Methods for Determining The Membrane-Water Partition Ratio for Surfactants

Steven Droge¹, Nina Jansen¹, Elin Barrett², Adriana C. Bejarano³, Jens Bietz⁴, Kristin Connors⁵, James Dawick⁶, Marc Geurts⁷, Geoffrey Hodges², Eoin Kearney⁸, Mark Miller⁸, Diederik Schowanek⁹ and Sabrina Wilhelm¹⁰, (1)Environmental Risk Assessment, Wageningen University & Research (WUR), Wageningen, Netherlands, (2)Safety and Environmental Assurance Centre, Unilever Research, Bedford, United Kingdom, (3)Shell Global Solutions, (4)Clariant Produkte (Deutschland) GmbH, Frankfurt am Main, Germany, (5)Procter & Gamble, Mason, (6)Innospec Limited, United Kingdom, (7)Nouryon Chemicals B.V., Arnhem, Netherlands, (8)Department of Chemistry, Durham University, Durham, United Kingdom, (9)Brussels Innovation Centre, Procter & Gamble, Brussels, Belgium, (10)BASF Personal Care and Nutrition GmbH, Germany

3.12.P-Tu247 - Coarse-Grained Simulations of Passive Partitioning of Ionic Surfactants into Cell Membranes

Eoin Kearney¹, Mark Miller¹, Elin Barrett², Adriana C. Bejarano³, Jens Bietz⁴, Kristin Connors⁵, James Dawick⁶, Steven Droge⁷, Marc Geurts⁸, Geoffrey Hodges², Diederik Schowanek⁹ and Sabrina Wilhelm¹⁰, (1)Department of Chemistry, Durham University, Durham, United Kingdom, (2)Unilever R&D Colworth, United Kingdom, (3)Shell Global Solutions, (4)Clariant Produkte (Deutschland) GmbH, Frankfurt am Main, Germany, (5)Procter & Gamble, (6)Innospec Limited, United Kingdom, (7)Environmental Risk Assessment, Wageningen University & Research (WUR), Wageningen, Netherlands, (8)Nouryon Chemicals B.V., Arnhem, Netherlands, (9)Brussels Innovation Centre, Procter & Gamble, Brussels, Belgium, (10)BASF Personal Care and Nutrition GmbH, Düsseldorf, Germany

4.02.P-Th443 - Assessing risks to biodiversity from exposure to chemicals: findings of an ECETOC Task Force on the regulatory context

Christoph Mayer¹, David A Bohan², Sian Ellis³, Anja Gladbach⁴, Volker Grimm⁵, Jutta Hellstern⁶, Geoffrey Hodges⁷, Sarah A. Hughes⁸, Philippe Lemaire⁹, Lorraine Maltby¹⁰, Anna-Maija Nyman¹¹, Michael Riffel¹², Hans Sanderson¹³, Aaron Stoler¹⁴, Marco Thines¹⁵, Johannes Tolls Dir¹⁶, Nico van den Brink¹⁷ and Nika Galic¹⁸, (1)BASF SE, Germany, (2)INRAe, (3)Corteva Agriscience, Abingdon, United Kingdom, (4)Bayer AG - Crop Science Division, ., Germany, (5)Helmholtz Centre for Environmental Research – UFZ, Germany, (6)F. Hoffmann-La Roche, (7)Unilever - Safety and Environmental Assurance Centre (SEAC), United Kingdom, (8)Shell Global Solutions, (9)Total Special Fluids Division, France, (10)School of Biosciences, University of Sheffield, Sheffield, United Kingdom, (11)European Chemicals Agency (ECHA), Helsinki, Finland, (12)RIFCON GmbH, Hirschberg, Germany, (13)Aarhus University, Denmark, (14)Exxon Mobil, Cypress, United States, (15)Goethe University, (16)Corporate Scientific Services, Henkel AG & Co. KGaA, Düsseldorf, Germany, (17)Division of Toxicology, Wageningen University & Research, Wageningen, Netherlands, (18)Syngenta AG, Switzerland

1.02.P-Mo003 - Ecdysone Receptor Agonism Adverse Outcome Pathway Validation for Insect-Specific In Vitro Assay Development (PDF 464.9 KB)

Rebeka Darmati¹, Paul Carmichael², Bruno Campos² and Nico van den Brink¹, (1)Division of Toxicology, Wageningen University & Research, Wageningen, Netherlands, (2)Unilever - Safety and Environmental Assurance Centre (SEAC), United Kingdom

1.08.P-Mo054 - Using Comparative Genomics to Develop ‘Digital Twins’ to Support Ecotoxicological Predictions (PDF 1.98 MB)

Rama Krishnan¹, David Spurgeon², Stephen James Short³, Bruno Campos⁴, Claudia Rivetti⁴, Claire Peart⁴ and Peter Kille¹, (1)Cardiff University, United Kingdom, (2)UK Centre for Ecology & Hydrology (UKCEH), Wallingford, United Kingdom, (3)Pollution, UK Centre for Ecology & Hydrology (UKCEH), United Kingdom, (4)Unilever - Safety and Environmental Assurance Centre (SEAC), Unilever, United Kingdom

1.11.P-Th067 - Addressing the challenges of Acute Toxicity Hazard Classification using a non-animal Defined Approach

Donna S. Macmillan¹, Pravin Ambure², Yannick Bayona³, Vera Bonderovic⁴, James Dawick⁵, Nicolas Fabre³, Stephan Fischer⁶, Geoffrey Hodges⁷, Ágata Llobet Mut², Sophie Loisel-Joubert³, Jayne Roberts⁷, Eva Serrano Candelas², Blanca Serrano⁸, Claudia Rivetti⁷, Kristin Schirmer⁹ and Ricky Stackhouse¹⁰, (1)HSI, (2)ProtoQSAR, Spain, (3)L'Oréal Research & Innovation, France, (4)BioRevivo, (5)Innospec Limited, United Kingdom, (6)aQuaTox-Solutions GmbH, Switzerland, (7)Unilever - Safety and Environmental Assurance Centre (SEAC), United Kingdom, (8)ECETOC, Brussels, Belgium, (9)Environmental Toxicology, Swiss Federal Institute of Aquatic Science and Technology (Eawag), Dübendorf, Switzerland, (10)Sasol, Houston, Texas

1.11.P-Th069 - MechoA+: use, versatility and structural diversity (PDF 1.56 MB)

Gaspard Levet¹, Franklin Bauer¹, James W. Firman², Bruno Campos³, Steve Gutsell³, Jayne Roberts³, Mark A. Bonnell⁴, Paul Thomas¹, Mark Cronin² and Geoffrey Hodges³, (1)KREATiS SAS, L'Isle d'Abeau, France, (2)Liverpool John Moores University, United Kingdom, (3)Unilever - Safety and Environmental Assurance Centre (SEAC), United Kingdom, (4)Department of Environment and Climate Change Canada

3.17.P-Tu295 - Building Knowledge from Available Degradation Simulation Studies to Improve their Usability

Louise Camenzuli¹, Michael Earl², Katie Endersby^3,4, Kathrin Fenner⁵, Richard Gibson⁶, Patricia Anna Golombek⁷, Jasmin Hafner⁸, Damian Helbling⁹, Christopher Hughes¹⁰, Aurelia Lapczynski¹¹, Sven Peter¹², David MV Saunders¹³, Chiara Maria Vitale¹⁴, Neil Wang¹⁵, Miriam Leon Paumen¹⁶, lemaire philippe¹⁷, Johannes Tolls Dir¹⁸ and Marie Collard¹⁹, (1)ExxonMobil, Belgium, (2)Syngenta Ltd.,, Jealott’s Hill, United Kingdom, (3)School of Life Sciences, University of Warwick, Coventry, United Kingdom, (4)Safety and Environmental Assurance Centre (SEAC), Unilever, Colworth Science Park, United Kingdom, (5)Swiss Federal Institute of Aquatic Science and Technology (Eawag), Dübendorf, Switzerland, (6)UK Environment Agency, United Kingdom, (7)RG/TC, BASF SE, Germany, (8)Environmental Chemistry, Swiss Federal Institute of Aquatic Science and Technology (Eawag), Dübendorf, Switzerland, (9)Cornell University, (10)Ricardo, Harwell, United Kingdom, (11)Research Institute for Fragrance Materials, Woodcliff Lake, NJ, (12)GBP/RA, BASF SE, Germany, (13)Shell Global Solutions, ., Netherlands, (14)Procter & Gamble, Mason, United States, (15)Solvay, Lyon, France, (16)ExxonMobil Biomedical Sciences, Inc., Machelen, Belgium, (17)Total, (18)Corporate Scientific Services, Henkel AG & Co. KGaA, Düsseldorf, Germany, (19)DSM-Firmenich, Belgium

3.17.P-Tu296 - How do River Channel Geometry and Sediment Calibre Affect the Degradation of Wastewater Pollutants? Insights from a Laboratory Experiment (PDF 7.42 MB)

Robert Newbould¹, Mark Powell¹, Alexandre Teixeira², Juliet Hodges² and Mick Whelan¹, (1)School of Geography, Geology and the Environment, University of Leicester, United Kingdom, (2)Safety & Environmental Assurance Centre, Unilever, Sharnbrook, United Kingdom

3.02.P-We119 - Estimating Marine Chemical Emissions from Discharges of Sewage Treatment Plants into Freshwater Rivers (PDF 857.88 KB)

Logan Insinga¹, Christopher M Holmes¹ and Juliet Hodges², (1)Applied Analysis Solutions, LLC, (2)Safety & Environmental Assurance Centre, Unilever, Sharnbrook, United Kingdom

6.02.P-We501 - Addressing the Impact of the Mixture Allocation Factor (MAF) on Environmental Risk Assessment: Refining Regulatory Exposure Predictions Using Spatial Data and Modelling Approaches

Christopher M Holmes¹, Logan Insinga¹, Juliet Hodges², Jens Bietz³, Liesa-Kristin Beuter Beuter⁴, Geoffrey Hodges², Diederik Schowanek⁵, James Dawick⁶, Erin Maloney⁷, Marc Geurts⁸, Sabrina Wilhelm⁹, Susan A Csiszar¹⁰ and Henrique Anselmo¹¹, (1)Applied Analysis Solutions, LLC, (2)Safety & Environmental Assurance Centre, Unilever, Sharnbrook, United Kingdom, (3)Clariant Produkte (Deutschland) GmbH, Frankfurt am Main, Germany, (4)Nouryon AB, Niefern-Öschelbronn, Sweden, (5) Brussels Innovation Centre, Procter & Gamble, Brussels, Belgium, (6)Innospec Limited, United Kingdom, (7)Shell Global Solutions International BV, Den Haag, Netherlands, (8)Nouryon Chemicals B.V., Arnhem, Netherlands, (9)BASF Personal Care and Nutrition GmbH, Düsseldorf, Germany, (10)Procter & Gamble, Belgium, (11)Global Safety Assurance, Reckitt, Netherlands

3.17.P-Tu291 - Biodegradable or not? Developing a standardized international approach to assessing the biodegradability of cosmetic formulations

Silke Fiebig¹, Juliet Hodges², Amelie Ott³, Ryan Heisler³, Karina J Reynolds⁴, Andrea Carrao⁵, Guillaume Cottin⁶, Jennifer Dorts⁷, Judith Kaumanns⁸, Monica Lam⁹, Fanny Minetto¹⁰, Beta Montemayor¹¹, Jennifer K. Saxe¹², Harald Streicher¹³, Cyril Sweetlove¹⁴ and Nadin Wedler¹⁵, (1)Vitis Regulatory, Pean Hill, United Kingdom, (2)Safety & Environmental Assurance Centre, Unilever, Sharnbrook, United Kingdom, (3)International Collaboration on Cosmetics Safety (ICCS), New York, (4)WSP E&I, United Kingdom, (5)Kao USA, (6)L'OREAL, France, (7)IFRA, (8)Product Safety & Regulatory Affairs, Wella Company, Darmstadt, Germany, (9)Procter & Gamble, ., United States, (10)Chanel, (11)Science, Regulation and Market Access, Cosmetics Alliance Canada, Mississauga, Canada, (12)Kenvue, (13)Beiersdorf, Hamburg, Germany, (14)L'Oréal, ., France, (15)Kao Germany GmbH, ., Germany

2.04.P-Tu077 - Multiple contaminants in complex communities: evaluating non-additive effects of multiple simultaneous stressors on biomass flux and ecosystem functioning (PDF 2.38 MB)

Hana B Mayall¹, Lorraine Maltby¹, Dylan Z Childs¹, Claudia Rivetti², Andrea Gredelj³ and Andrew Beckerman¹, (1)School of Biosciences, University of Sheffield, Sheffield, United Kingdom, (2)Unilever - Safety and Environmental Assurance Centre (SEAC), United Kingdom, (3)Norwegian Geotechnical Institute (NGI), Oslo, Norway

4.04.P-We327 Predicting Extinctions in Food Webs (PDF 197.87 KB)

Thomas Malpas¹, Lorraine Maltby², Claudia Rivetti³ and Andrea Gredelj³, (1)University of Sheffield, Sheffield, United Kingdom, (2)School of Biosciences, University of Sheffield, Sheffield, United Kingdom, (3)Unilever - Safety and Environmental Assurance Centre (SEAC), United Kingdom

1.02.P-Mo002 - Screening Chemicals Using High-Throughput Phenotypic Profiling (HTPP) in Two Zebrafish Cell Lines (PDF 1.44 MB)

Felix Harris¹, Clinton Willis², Bruno Campos³, Geoffrey Hodges³, Sophie Cable³, Alistair Middleton³, Amanda Jurgelewicz⁴, Richard Judson² and Joshua Austell Harrill², (1)ORISE Participant at U.S. Environmental Protection Agency, (2)U.S. Environmental Protection Agency, (3)Unilever - Safety and Environmental Assurance Centre (SEAC), United Kingdom, (4)ORISE Participant at the U.S. Environmental Protection Agency

1.02.P-Mo005 - Breaking the silos: Towards a holistic approach of animal-free human and environmental health safety assessments of cosmetics

Amelie Ott¹, Ryan Heisler¹, David Allen², Arnaud Boivin³, Maria Baltazar⁴, Bruno Campos⁵, Christopher Choi⁶, Carol Courage⁷, Iain Davies⁸, Nazanin Golbamaki⁹, Juliet Hodges¹⁰, Abdulkarim Najjar¹¹, Véronique Poulsen¹², Gladys Ouedraogo⁹, Andreas Schepky¹¹ and Harald Streicher¹¹, (1)International Collaboration on Cosmetics Safety (ICCS), New York, (2)Integrated Laboratory Systems, Inc., (3)L'Oréal, France, (4)Unilever, (5)Unilever - Safety and Environmental Assurance Centre (SEAC), United Kingdom, (6)Takasago, (7)Croda, (8)PCPC (Personal Care Products Council), (9)L'Oréal, (10)Safety & Environmental Assurance Centre, Unilever, Sharnbrook, United Kingdom, (11)Beiersdorf, Germany, (12)l'OREAL, France

3.17.P-Tu287 - New Approaches to Persistence Testing With Increased Cell Number Using Tangential Flow Filtration (PDF 1.17 MB).

Katie Endersby, Dave Gore and Chris Finnegan, Safety and Environmental Assurance Centre (SEAC), Unilever, Colworth Science Park, United Kingdom

4.02.P-Th444 - Assessing Risks to Biodiversity from Exposure to Chemicals: Findings of an ECETOC Task Force on Current and Future Research Directions

Anja Gladbach¹, David A Bohan², Sian Ellis³, Volker Grimm⁴, Jutta Hellstern⁵, Geoffrey Hodges⁶, Sarah A. Hughes⁷, Philippe Lemaire⁸, Lorraine Maltby⁹, Christoph Mayer¹⁰, Anna-Maija Nyman¹¹, Michael Riffel¹², Hans Sanderson¹³, Aaron Stoler¹⁴, Marco Thines¹⁵, Johannes Tolls Dir¹⁶, Nico van den Brink¹⁷ and Nika Galic¹⁸, (1)Bayer AG - Crop Science Division, Germany, (2)INRAe, (3)Corteva Agriscience, Abingdon, United Kingdom, (4)Helmholtz Centre for Environmental Research – UFZ, Germany, (5)F. Hoffmann-La Roche, (6)Unilever - Safety and Environmental Assurance Centre (SEAC), United Kingdom, (7)Shell Global Solutions, (8)Total Special Fluids Division, France, (9)School of Biosciences, University of Sheffield, Sheffield, United Kingdom, (10)BASF SE, Germany, (11)European Chemicals Agency (ECHA), Helsinki, Finland, (12)RIFCON GmbH, Hirschberg, Germany, (13)Aarhus University, Denmark, (14)Exxon Mobil, Cypress, United States, (15)Goethe University, (16)Corporate Scientific Services, Henkel AG & Co. KGaA, Düsseldorf, Germany, (17)Division of Toxicology, Wageningen University & Research, Wageningen, Netherlands, (18)Syngenta AG, Switzerland

3.07.P-Th301 - Biodegradability of Water-Soluble and Water-Dispersible Polymers in Respirometric Laboratory Methods

Glauco Battagliarin¹, Kathleen McDonough², Marlies Bergheim Sr M³, Jared Bozich⁴, Katie Endersby⁵, Dave Gore⁵, Bjoern Hidding⁶, Christian Kastner Sr M³, Jan Robinson⁷, Georg Kreutzer⁸, Hans Leijs⁹, Jennifer Menzies¹⁰, Meera Raghuram¹¹ and Nathalie Vallotton¹², (1)Research Biopolymers, BASF SE, Ludwigshafen am Rhein, Germany, (2)P&G, Mason, OH, (3)Corporate Scientific Services, Henkel AG & Co. KGaA, Düsseldorf, Germany, (4)International Flavors and Fragrances, (5)Safety and Environmental Assurance Centre

8.08.P-Tu548 - MERCI: A tiered exposure modeling framework to support the environmental risk assessment of cosmetic ingredients directly discharged into natural waters.

Ryan Heisler¹, W. Martin Williams², Maura Roberts², Todd Gouin³, Scott Dyer², Amelie Ott¹, Sascha Pawlowski⁴, Juliet Hodges⁵, Arnaud Boivin⁶, Eva Klingelmann⁷ and Ahmed Tlili⁸, (1)International Collaboration on Cosmetics Safety (ICCS), (2)Waterborne Environmental, Inc., (3)TG Environmental Research, United Kingdom, (4)GBP/RA, BASF SE, Germany, (5)Safety & Environmental Assurance Centre, Unilever, Sharnbrook, United Kingdom, (6)L'Oréal, France, (7)Symrise AG, Germany, (8)Personal Care, DSM-Firmenich, Switzerland